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describes the weight loss benefits of EGCG and how it works with 5-HTP, delicious.com

The head of a prominent cancer research institute issued an unprecedented warning to his faculty and staff Wednesday: Limit cell phone use because of the possible risk of cancer., delicious.com

American Journal of Epidemiology, Vol. 165, No. 1. (1 January 2007), pp. 36-43.Boffetta, Paolo, van der Hel, Olga, Norppa, Hannu, Fabianova, Eleonora, Fucic, Aleksandra, Gundy, Sarolta, Lazutka, Juozas, Cebulska-Wasilewska, Antonina, Puskailerova, Daniela, Znaor, Ariana, Kelecsenyi, Zsolt, Kurtinaitis, Juozas, Rachtan, Jadwiga, Forni, Alessandra, Vermeulen, Roel, Bonassi, Stefano, citeulike.org

Cancer research, Vol. 64, No. 6. (15 March 2004), pp. 2258-2263.The frequency of cells with structural chromosomal aberrations (CAs) in peripheral blood lymphocytes is the first genotoxicity biomarker that has shown an association with cancer risk. CAs are usually divided into chromosome-type (CSAs) and chromatid-type aberrations (CTAs), with different mechanisms of formation. From a mechanistic point of view, it is of interest to clarify whether the cancer predictivity of CAs is different with respect to CSAs and CTAs. We report here cancer risk for cytogenetically tested, healthy subjects with respect to frequency of CAs, CSAs, and CTAs in peripheral blood lymphocytes, using Nordic (1981 subjects with CA data, 1871 subjects with CSA/CTA data) and Italian (1573 subjects with CA data, 877 subjects with CTA/CSA data) cohorts, with a median follow-up of 17 years. High levels of CAs at test were clearly associated with increased total cancer incidence in the Nordic cohorts and increased total cancer mortality in the Italian cohort. In the Nordic cohorts, significantly elevated cancer risks were observed for subjects with both high CSAs and high CTAs at test, and these variables showed equally strong cancer predictivity. The results of the Italian cohort did not indicate any clear-cut difference in cancer predictivity between the CSA and CTA biomarkers. There was no significant effect modification by age at test, gender, country, or time since test. The results suggest that both DNA double-strand breaks and other initial DNA lesions responsible for CSAs and CTAs are associated with cancer risk.L Hagmar, U Strömberg, S Bonassi, IL Hansteen, LE Knudsen, C Lindholm, H Norppa, citeulike.org

Carcinogenesis, Vol. 29, No. 6. (19 March 2008), pp. 1178-1183.Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results of epidemiological studies which associated CA frequency in peripheral lymphocytes of healthy individuals to future cancer incidence. To overcome the limitations of single studies and to evaluate the strength of this association a pooled analysis was carried out. The pooled database included 11 national cohorts and a total of 22,358 cancer free individuals who underwent genetic screening with CA for biomonitoring purposes during 1965-2002 and were followed up for cancer incidence and/or mortality for an average of 10.1 years; 368 cancer deaths and 675 incident cancer cases were observed. Subjects were classified within each laboratory according to tertiles of CA frequency. The relative risk (RR) of cancer was increased for subjects in the medium (RR = 1.31; 95% confidence interval (CI) 1.07-1.60) and in the high (RR = 1.41; 95% CI 1.16-1.72) tertiles, when compared with the low tertile. This increase was mostly driven by chromosome-type aberrations. The presence of ring chromosomes increased the RR to 2.22 (95% CI= 1.34-3.68). The strongest association was found for stomach cancer (RR(medium)=1.17 (95% CI= 0.37-3.70); RR(high)=3.13 (95% CI= 1.17-8.39)). Exposure to carcinogens did not modify the effect of CA levels on overall cancer risk. These results reinforce the evidence of a link between CA frequency and cancer risk and provide novel information on the role of aberration subclass and cancer type.Stefano Bonassi, Hannu Norppa, Marcello Ceppi, Ulf Stromberg, Roel Vermeulen, Ariana Znaor, Antonina Cebulska-Wasilewska, Eleonora Fabianova, Alexandra Fucic, Sarolta Gundy, Inger-Lise Hansteen, Lisbeth Knudsen, Juozas Lazutka, Pavel Rossner, Radim Sram, Paolo Boffetta, citeulike.org