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"In this study we describe a novel Rho small GTPase dependent pathway that elicits apoptotic responses controlled by actin reorganization in hormone-sensitive LNCaP- and hormone insensitive DU145-prostate cancer cells stimulated with membrane androgen receptor selective agonists. Using an albumin-conjugated steroid, testosterone-BSA, we now show significant induction of actin polymerization and apoptosis that can be reversed by actin disrupting agents in both cell lines. Testosterone-BSA triggered RhoA/B and Cdc42 activation in DU145 cells followed by stimulation of downstream effectors ROCK, LIMK2 and ADF/destrin. Furthermore, dominant-negative RhoA, RhoB or Cdc42 mutants or pharmacological inhibitors of ROCK inhibited both actin organization and apoptosis in DU145 cells. Activation of RhoA/B and ROCK was also implicated in membrane androgen receptor-dependent actin polymerization and apoptosis in LNCaP cells. Our findings suggest that Rho small GTPases are major membrane androgen receptor effectors controlling actin reorganization and apoptosis in prostate cancer cells" Posted by taniusha to DU145 LNCaP prostate Apoptosis on Wed Nov 12 2008, connotea.org

"Weight linked to prostate cancer death" Posted by kungfucancer with 1 comment to cure prostate cancer on Mon Oct 27 2008, connotea.org

"Prostate cancer" Posted by KScorpio1 to ECGC prostate cancer on Tue Oct 28 2008, connotea.org

Posted by jls1948 to rank osteoclasts Metastasis prostate on Thu Nov 06 2008, connotea.org

"What may we say about fat? It is simply one of three dietary molecules that the body uses per day to get the organism system to function. (...)" Posted by TheProstate (who is an author) with 1 comment to meat red prostate Fat cancer on Wed Nov 12 2008, connotea.org

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