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Prostacet provides a comprehensive blend of Vitamins, minerals and standardized herbal extracts designed to support healthy prostate function., delicious.com

Radiology, Vol. 246, No. 1. (January 2008), pp. 177-184.PURPOSE: To retrospectively compare relative accuracy of different interpretative approaches to magnetic resonance (MR) and MR spectroscopic imaging of peripheral zone prostate cancer, by using histologic examination results as the reference standard. MATERIALS AND METHODS: This HIPAA-compliant study had institutional Committee on Human Research approval, with waiver of written consent requirement. Spectroscopic voxels of unequivocally benign (n = 66) or malignant (n = 77) peripheral zone tissue were identified by using step-section histopathologic tumor maps created for 28 men (mean age, 60 years; range, 46-71 years) who underwent endorectal MR and MR spectroscopic imaging before radical prostatectomy. Two readers (9 and 8 years of experience) independently scored the selected voxels on a scale from 1 (likely benign) to 5 (likely malignant) at randomized review of the corresponding tissue outlined on a transverse T2-weighted MR image (T2 approach), the MR spectrum from the selected voxel only (single-voxel approach), the MR spectra from all voxels at the same axial level (multivoxel approach), and both the corresponding tissue outlined on a transverse T2-weighted image and the MR spectra from all voxels at the same axial level (integrated approach). Readers were aware that spectra were derived in patients with biopsy-proved diagnoses of prostate cancer and represented either benign or malignant tissue but were unaware of which voxels had been labeled benign or malignant and of all other clinical, histopathologic, and MR imaging findings. Receiver operating characteristic (ROC) curve analysis was performed. Generalized estimating equation method was used to estimate sensitivity and specificity for specific cutoff values. RESULTS: Mean areas under the ROC curve (AUCs) for the T2, single-voxel, multivoxel, and integrated approaches were 0.69, 0.72, 0.72, and 0.76, respectively. AUC of the integrated approach was significantly higher than those of the other three approaches (P < .001). kappa Values for assessment of interobserver variability for the T2, single-voxel, multivoxel, and integrated approaches were 0.39, 0.39, 0.34, and 0.48, respectively. CONCLUSION: Addition of MR spectroscopic imaging to MR imaging significantly improves characterization of peripheral zone prostate tissue as benign or malignant; improved performance is obtained when both data sets are interpreted in an integrated fashion.AC Westphalen, FV Coakley, A Qayyum, M Swanson, JP Simko, Y Lu, S Zhao, PR Carroll, BM Yeh, J Kurhanewicz, citeulike.org

BMC Urology, Vol. 7 (24 July 2007), 12.Kent Nastiuk, Hui Liu, Mark Hamamura, Tugan Muftuler, Orhan Nalcioglu, John Krolewski, citeulike.org

Prostacet provides a comprehensive blend of Vitamins, minerals and standardized herbal extracts designed to support healthy prostate function., delicious.com

Prostacet provides a comprehensive blend of Vitamins, minerals and standardized herbal extracts designed to support healthy prostate function., delicious.com

Prostacet provides a comprehensive blend of Vitamins, minerals and standardized herbal extracts designed to support healthy prostate function., delicious.com

Neoplasia (New York, N.Y.), Vol. 4, No. 3. (n 2002), pp. 255-262.For many anticancer therapies, it would be desirable to accurately monitor and quantify tumor response early in the treatment regimen. This would allow oncologists to continue effective therapies or discontinue ineffective therapies early in the course of treatment, and hence, reduce morbidity. This is especially true for second-line therapies, which have reduced response rates and increased toxicities. Previous works by others and ourselves have shown that water mobility, measured by diffusion-weighted magnetic resonance imaging (DW-MRI), increases early in tumors destined to respond to therapies. In the current communication, we further characterize the utility of DW-MRI to predict response of prostate cancer xenografts to docetaxel in SCID mice in a preclinical setting. The current data illustrate that tumor volumes and secreted prostate-specific antigen both respond strongly to docetaxel in a dose-responsive manner, and the apparent diffusion coefficient of water (ADC(w)) increases significantly by 2 days even at the lowest doses (10 mg/kg). The ADCw data were parsed by histogram analyses. Our results indicate that DW-MRI can be used for early detection of prostate carcinoma xenograft response to docetaxel chemotherapy.D Jennings, BN Hatton, J Guo, JP Galons, TP Trouard, N Raghunand, J Marshall, RJ Gillies, citeulike.org

Journal of Magnetic Resonance Imaging, Vol. 13, No. 4. (2001), pp. 607-614.Quantitative analysis of contrast-enhanced dynamic MR images has potential for diagnosing prostate cancer. Contemporary fast acquisition techniques can give sufficiently high temporal resolution to sample the fast dynamics observed in the prostate. Data reduction for parametric visualization requires automatic curve fitting to a pharmacokinetic model, which to date has been performed using least-squares error minimization methods. We observed that these methods often produce unexpectedly noisy estimates, especially for the typically fast, intermediate parameters time-to-peak and start-of-enhancement, resulting in inaccurate pharmacokinetic parameter estimates. We developed a new curve fit method that focuses on the most probable slope. A set of 10 patients annotated using histopathology was used to compare the conventional and new methods. The results show that our new method is significantly more accurate, especially in the relatively less-enhancing periferal zone. We conclude that estimation accuracy depends on the curve fit method, which is especially important when evaluating the periferal zone of the prostate. J. Magn. Reson. Imaging 2001;13:607-614. © 2001 Wiley-Liss, Inc.Henkjan Huisman, Marc Engelbrecht, Jelle Barentsz, citeulike.org