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Posted by okrent to pregabalin on Thu May 12 2005, connotea.org

Posted by fauman (who is an author) to a2d pregabalin on Wed Sep 12 2007, connotea.org

Posted by okrent to pregabalin on Thu May 12 2005, connotea.org

Posted by okrent to pregabalin on Thu May 12 2005, connotea.org

Posted by okrent to pregabalin on Thu May 12 2005, connotea.org

Posted by abipaul7 to pregabalin pain on Sat Aug 09 2008, connotea.org

Nature clinical practice. Neurology (14 October 2008)This Practice Point commentary discusses the first two trials of long-term drug treatment in fibromyalgia. In Russell et al.'s study, 33% of patients receiving 6-month treatment with 60 mg/day duloxetine responded to therapy; the number needed to treat was seven. In the three treatment arms, 15% (60 mg/day duloxetine), 27% (120 mg/day duloxetine) and 13% (placebo) of patients discontinued treatment because of adverse events (the most common being nausea and fatigue ). In Crofford et al.'s study, 32% of patients who received pregabalin had loss of therapeutic response, compared with 61% of patients treated with placebo. The discontinuation rate due to adverse events (dizziness in 36% of cases and somnolence in 22%) during the randomized treatment phase was 16% with pregabalin and 7% with placebo. This commentary discusses the implications of these trials for clinical practice and considers areas for future research in the field. In view of the current results, duloxetine and pregabalin could be administered together and as part of multimodal and multidisciplinary therapy, but treatment should 'start low and go slow'.Eric Serra, citeulike.org

Pain (14 May 2007)Pregabalin has anticonvulsant, antihyperalgesic, and anxiolytic properties. In this study we evaluated the control of pain after perioperative administration of pregabalin 300 or 600mg, compared with diazepam 10mg. Altogether 91 women scheduled for laparoscopic hysterectomy were randomized to receive diazepam 10mg (D10), pregabalin 150mg (P300) or 300mg (P600) for premedication, and the dose was repeated after 12h, except for the D10 group, in which the patients received placebo. Up until the 1st postoperative morning, analgesia was provided by oxycodone using patient controlled analgesia. The visual analogue scale scores for pain and side effects, and the amounts of the analgesics were recorded for three days after surgery. The doses of oxycodone during hours 0-12 after surgery were similar in the three groups, whereas the dose of oxycodone during hours 12-24 after surgery was smaller in the P600 group than in the P300 group (0.09 vs. 0.16mgkg(-1); P=0.025). The total dose of oxycodone (0-24h after surgery) was smaller in the P600 group than in the D10 group (0.34 vs. 0.45mgkg(-1); P=0.046). The incidence of dizziness (70% vs. 35%; P=0.012), blurred vision (63% vs. 14%; P=0.002) and headache (31% vs. 7%; P=0.041) were higher in the P600 group than in the D10 group. In conclusion, perioperative administration of pregabalin 600mg decreases oxycodone consumption compared with diazepam 10mg, but is associated with an increased incidence of adverse effects.Ritva Jokela, Jouni Ahonen, Minna Tallgren, Maija Haanpää, Kari Korttila, citeulike.org

Nat Clin Pract Rheum, Vol. 4, No. 10. (October 2008), pp. 514-515.Michael Spaeth, citeulike.org